not spondyloarthritis with disease activity in rheumatoid arthritis but Systemic levels of IL - 23 are strongly associated
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چکیده
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Association of IL-10 rs1800896 (-1082 G/A) gene polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran
Background and objectives: Rheumatoid arthritis (RA) is a complex and systemic inflammatory disease in which the immune response is disturbed. Single nucleotide polymorphisms (SNPs) in the promoter regions of regulatory cytokines including interleukin-10 (IL-10) may lead to exacerbated immune response and increased risk of RA. Here, we aimed to assess the association of IL-10 -1082 (G/A) (rs180...
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Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...
متن کاملتغییرات سطح سرمی هپسیدین و ارتباط آن با سطح فاکتورهای التهابی و فعالیت بیماری آرتریت
Background and Objectives: Rheumatoid arthritis (RA) disease is a common inflammatory arthritis associated with joint destruction, motor disorder, and decreased life span. Hepcidin is an acute phase reactant protein which increases in inflammatory conditions mediated by IL-6 and its concentration elevates within the cell through regulating iron metabolism. The aim of this study was to evaluate ...
متن کاملInvestigation of the relation between the hypothalamus-pituitary-adrenal (HPA) axis activity, IL-6 and hyperalgesia during chronic inflammation due to rheumatoid arthritis (RA) in male rats.
Introduction: The activity of Hypothalamus-Pituitary-Adrenal (HPA) axis is increased following inflammation due to its closed relation with immune system. This axis indicates an increased secretion of ACTH, and corticosterone during acute inflammation while little is known about its activity during chronic inflammation such as rheumatoid arthritis (RA). In this study we measured the products...
متن کاملO4: Central Nervous System Involvement in Rheumatoid Arthritis: Possible Role of Chronic Inflammation and TNF Blocker Therapy
Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to bl...
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